A Covered Contractor Information System (CCIS) refers to an information system that is owned or operated by a contractor or subcontractor that processes, stores, or transmits Controlled Unclassified Information (CUI) on behalf of the US Government.
In the context of Cybersecurity Maturity Model Certification (CMMC) and NIST SP 800-171, a CCIS is the environment where CUI is handled and thus must comply with specific cybersecurity requirements.
A CCIS:
The security of a CCIS is critical because contractors that fail to protect CUI risk penalties, contract loss and damage to national security.